Signaling in Human Blood Vessels With and Without Nitroglycerin Pretreatment Functional and Biochemical Analysis of Endothelial (Dys)function and NO/cGMP
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چکیده
Silke Woelken-Weckmüller, Ulrich Walter, Hermann Reichenspurner, Thomas Meinertz and Eberhard Schulz, Nikolaus Tsilimingas, Ruth Rinze, Beate Reiter, Maria Wendt, Mathias Oelze, Signaling in Human Blood Vessels With and Without Nitroglycerin Pretreatment Functional and Biochemical Analysis of Endothelial (Dys)function and NO/cGMP Print ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 2002 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Circulation doi: 10.1161/hc1002.105186 2002;105:1170-1175; originally published online February 18, 2002; Circulation. http://circ.ahajournals.org/content/105/10/1170 World Wide Web at: The online version of this article, along with updated information and services, is located on the
منابع مشابه
Functional and biochemical analysis of endothelial (dys)function and NO/cGMP signaling in human blood vessels with and without nitroglycerin pretreatment.
BACKGROUND In experimental animal models, long-term in vivo treatment with nitroglycerin (NTG) induces both endothelial dysfunction and tolerance to nitrates. However, it is still controversial whether nitrate tolerance in humans is associated with both endothelial dysfunction and impaired vascular response to nitrovasodilator-derived NO. METHODS AND RESULTS Patients undergoing elective bypas...
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Accumulating evidence indicates that aldosterone plays a critical role in the mediation of oxidative stress and vascular damage. NADPH oxidase has been recognized as a major source of oxidative stress in vasculature. However, the relation between NADPH oxidase in aldosterone-mediated oxidative stress in endothelial cells remains to be ascertained. The present study aimed to investigate the rel...
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Nitric oxide (NO) and atrial natriuretic peptides (ANP) activate soluble (sGC) and particulate guanylate cyclase (pGC), respectively, and play important roles in the maintenance of cardiovascular homeostasis. However, little is known about potential interactions between these two cGMP-generating pathways. Here we demonstrate that sGC and pGC cooperatively regulate cGMP-mediated relaxation in hu...
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Introduction: Nitroglycerin is a fast-acting drug that rapidly dilates coronary arteries and thus increases blood flow to these vessels, and increases the blood flow through the lateral vessels to low blood areas. It also reduces both end diastolic pressure and volume of the left ventricular. However, the effect of nitroglycerin on the circulation hemodynamic is not known. Caro...
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تاریخ انتشار 2002